适用于平行合成工作流程的智能软件驱动自动化工作站

模块化自动合成自动化工作站

Chemspeed’s Synthesizer 模块化自动化工作站，允许在单一工作站上完成各种条件的自动化合成。Synthesizer工作站的灵活性可实现完整工作流程的全自动化，包括试剂制备 (液体和固体)、多步合成、后处理、纯化、分析和产品转移存储。工作站结合了全自动合成与创新性化学品操作技术，可像操作液体一样方便而准确进行固体操作。

适用于制药、农用化学品、精细和特种化学品、聚合物和催化剂、材料科学、有机化学、生物化学和其它工业领域中具有挑战性的平行合成工作流程。

简便易用直观的工作流程任务驱动软件。
多种可选的可替换自动化工具，可与其它Chemspeed工作站交换使用。
强大的顶置式称重分配/进样技术。
独特的反应器模块和反应器阵列技术 – 可容纳多达12个Chemspeed反应器模块，内含192个反应容器，适用于几乎所有化学相关的应用方向。

技术指标

大量硬件和软件工具可选，可根据您的工作流程进行微调
可分配各种类型的化合物质至任何容器（小瓶、微孔板、试剂瓶、反应器和配方容器等）
多种反应器可选，体积从2至100ml：玻璃（一次性）或不锈钢；适用于液相和固相合成；也适用于常压和高压反应（最高达100bar压力）
高效温和的涡旋混合（最高达1400 rpm），可同时进行反应器内的其它实验操作
为敏感试剂/惰性反应条件/低温化学提供惰性气氛
自动后处理和分析：真空、过滤、蒸发、液液萃取、SPE纯化、结晶、Dean Stark、TLC，分析设备接口等
可在加热、冷却和振摇时通入反应器内进行其它所需的操作
适用温度范围宽（-70 至 +180°C，在参考反应器内测量和控制）

主要应用领域

应用报告

Assessment of the Reusability of Pd Complexes Supported on Fluorous Silica Gel as Catalysts for Suzuki Couplings下载
Automated reaction optimisation of the enantioselective alpha-arylation of aldehydes via SOMO catalysis下载
Automated Sample Preparation in Analytical Chemistry下载
Automated Synthesis of Dendritic Core-Shell Architectures with Click Chemistry下载
Automated Synthesis of Methacrylate (MA) Polymers using RAFT下载
Parameter Screening in Process Development – Ligand-free Heck Reactions下载
Speeding-up the Process from Substance Discovery to Commercialization下载
The Influence of Vortex Agitation on Biphasic Phase Transfer Catalyzed Reactions Carbene Addition下载

产品小册子

Synthesis

视频

利用 ISYNTH SWAVE 进行微波合成

Software-driven robotic platform for parallel synthesis workflows

Modular robotic platform for automated synthesis

Chemspeed's Synthesizer SLTII is a modular robotic platform enabling automated synthesis on a single platform under virtually any conditions. The versatility of the Synthesizer Platform allows full automation of complete workflows including reagent preparation (liquids and solids), multistep synthesis, workup, purification, analysis and product transfer to storage. It combines fully automated and unattended synthesis with innovative chemical handling techniques capable of dispensing solids as conveniently and accurately as liquids.

It is suitable for challenging parallel synthesis workflows in the pharmaceutical, agrochemical, fine and specialty chemicals, polymer and catalyst, material science, organic chemistry, biochemistry and other industries.

- Easy-to-use workflow task-driven software
- Wide selection of exchangeable robotic tools, interchangeable with other Chemspeed platforms
- Unrivalled overhead gravimetric dispensing/dosing technology
- Unique reactor block and reactor array technology – can hold up to 12 Chemspeed reactor blocks carrying up to 192 reaction vessels for virtually all kinds of chemistry-related applications

Specifications

A large choice of hardware and software tools allows fine-tuned adaptation to your workflow
Ability to dispense virtually any type of compound into any type of container (vial, microtiter plates, bottles, reactors, formulation vessels etc.)
Large choice of reactors with volume from 2 to 100 ml: glass (disposable) or stainless steel; for liquid and solid phase synthesis; also for ambient and elevated pressure (up to 100 bar)
Efficient yet gentle vortex mixing (up to 1,400 rpm), even while accessing the reactor
Inert atmosphere for sensitive reagents / inert reaction conditions / low-temperature chemistry
Automated work-up and analysis: vacuum, filtration, evaporation, liquid/liquid extraction, SPE purification, crystallization, Dean Stark, TLC, interface to analytical devices, etc.
Access to reactors while heating, cooling and shaking
Broad temperature range (-70 to +180ºC, measured and controlled in a reference reactor)

Main Applications